解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Drug resistance is one of the main obstacles to the successful treatment of cancer. The availability of agents that are highly effective against drug-resistant cancer cells is therefore essential. The present study was performed to examine the anticancer effects of evodiamine, a major constituent of the Chinese herb E...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgi041
更新日期:2005-05-01 00:00:00
abstract::Recent studies have shown opposing effects of n-6 and n-3 fatty acids on the development of cancer and suggest a role for the ratio of n-6 to n-3 fatty acids in the control of cancer. However, whether an alteration in the n-6/n-3 fatty acid ratio of cancer cells affects their invasive potential has not been well inves...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgi019
更新日期:2005-04-01 00:00:00
abstract::2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a mammary gland carcinogen present in the human diet. Herein, the expression of estrogen receptor alpha (ERalpha), estrogen receptor beta (ER beta) and progesterone receptor (PR) was examined in mammary gland carcinomas induced by PhIP in female Sprague-Dawley ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgi013
更新日期:2005-04-01 00:00:00
abstract::The administration of 4-hydroxybutyl(butyl)nitrosamine (OH-BBN) to male B6D2F1 mice yielded a high incidence of large palpable urinary bladder cancers. Since prior studies demonstrated chemopreventive effects of non-steroidal anti-inflammatory drugs (NSAIDs), we further explored the efficacy of the NSAID indomethacin ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh352
更新日期:2005-03-01 00:00:00
abstract::Reported habits of red meat consumption, particularly red meat that has been cooked to the degree termed 'well-done', is a positive risk factor for colorectal cancer. Under high, pyrolytic temperatures, heterocyclic amines (HCA) and benzo[a]pyrene (BP) molecules can form inside and on the surface of red meat, respecti...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh350
更新日期:2005-03-01 00:00:00
abstract::Barrett's esophagus (BE) and esophageal adenocarcinoma (ADC) is associated with reflux of duodenal contents. Cyclooxygenase (COX)-2 is over-expressed in BE and ADC, and supposedly contributes to esophageal carcinogenesis. The aim of this study is to investigate what effect a COX-2 inhibitor has on esophageal adenocarc...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh340
更新日期:2005-03-01 00:00:00
abstract::The present study was designed to evaluate whether etodolac, a cyclooxgenase-2 (COX-2)-specific inhibitor, could prevent chemically induced biliary carcinogenesis in bilioenterostomized hamsters. Syrian golden hamsters were subjected to choledochojejunostomy and then received subcutaneous injections of N-nitrosobis(2-...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh311
更新日期:2005-02-01 00:00:00
abstract::DNA-methyltransferase-3B (DNMT3B) plays an important role in the generation of aberrant methylation in carcinogenesis. Polymorphisms and haplotypes of the DNMT3B gene may influence DNMT3B activity on DNA methylation, thereby modulating the susceptibility to lung cancer. To test this hypothesis, we investigated the ass...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh307
更新日期:2005-02-01 00:00:00
abstract::We hypothesized that superoxide from Kupffer cells (KC) contributes to hepatocarcinogenesis. p47phox(-/-) mice, deficient in phagocyte NADPH oxidase and superoxide generation, received a single dose of the hepatocarcinogen diethylnitrosamine (DEN). The following hepatic effects were observed at time points between 30 ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh320
更新日期:2005-02-01 00:00:00
abstract::Caucasian renal transplant recipients from Queensland, Australia have the highest non-melanoma skin cancer (NMSC) risk worldwide. Although ultraviolet light (UVR) exposure is critical, genetic factors also appear important. We and others have shown that polymorphism in the glutathione S-transferases (GST) is associate...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh291
更新日期:2005-01-01 00:00:00
abstract::Tea polyphenolic constituents induce apoptosis in cancer cells but not in normal cells. To study the mechanism of this selective effect, we used the ornithine decarboxylase (ODC)/Ras double transgenic mouse model that develops spontaneous skin tumors due to over-expression of ODC and a v-Ha-ras transgene. Administrati...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh281
更新日期:2005-01-01 00:00:00
abstract::Oxidized DNA base lesions, such as thymine glycol (Tg) and 8-hydroxyguanine, are often toxic and mutagenic and have been implicated in carcinogenesis. To clarify whether NEIL1 protein, which exhibits excision repair activity towards such base lesions, is involved in gastric carcinogenesis, we examined 71 primary gastr...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh267
更新日期:2004-12-01 00:00:00
abstract::Flow cytometric analysis of fibroblasts, normal breast epithelial cells and breast or other cancer cell lines identified variation in the abilities of cell lines to undergo cell cycle arrest as a response to hypoxia. Human mammary epithelial cells (HMEC), normal fibroblasts (Hs68 and WI38), HeLa cervical carcinoma and...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh274
更新日期:2004-12-01 00:00:00
abstract::Retinoids have been shown to exert an anticarcinogenic effect through suppression of the cell cycle, induction of apoptosis and/or differentiation. In rat liver, in particular, retinoic acid has been shown to inhibit regeneration after partial hepatectomy, most probably through repression of the expression of c-fos an...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh221
更新日期:2004-11-01 00:00:00
abstract::Certain hexavalent chromium [Cr(VI)] compounds are implicated as occupational respiratory carcinogens. Cr(VI) induces a broad spectrum of DNA damage, but Cr(VI)-induced DNA double-strand breaks (DSBs) have not been reported. Previously we found that Cr(VI) activates the ataxia telangiectasia mutated (ATM) kinase. ATM ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh242
更新日期:2004-11-01 00:00:00
abstract::Hepatocyte growth factor (HGF)-stimulated Met signaling influences tumor survival, growth and progression, all processes involving the transcription factor NF-kappaB. NF-kappaB plays a complex role in the control of survival due to the influence of cellular factors acting downstream. We undertook a comparative investi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh227
更新日期:2004-11-01 00:00:00
abstract::Several members of the P450 family, including cytochrome P450 1B1 (CYP1B1), can convert tobacco smoke (TS) procarcinogens, including benzo[a]pyrene (B[a]P), to carcinogenic intermediates. In this study we investigated the effects of TS condensate and B[a]P on the expression of CYP1B1 in vitro and in vivo. CYP1B1 mRNA ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh243
更新日期:2004-11-01 00:00:00
abstract::Thioredoxin-1 is a low molecular weight redox protein that protects cells against oxidant damage. Thioredoxin-1 levels are increased in the epidermal layer of sun-damaged human skin. Thioredoxin-1 levels are also increased in several human primary tumors where its expression is associated with increased tumor cell pro...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh195
更新日期:2004-10-01 00:00:00
abstract::Zinc has been shown to be accumulated in N-methyl-N-nitrosourea (MNU)-induced rat mammary tumors. Zinc is required for cell proliferation and tumorigenesis is characterized by dysregulation of cell proliferation. An accumulation of zinc in mammary tumors perhaps indicates a reliance on zinc to sustain tumor growth. Li...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh214
更新日期:2004-10-01 00:00:00
abstract::A number of distinct subtypes of neuroblastoma exist with different genetic abnormalities that are predicative of outcome. Whole chromosome gains are usually associated with low stage disease and favourable outcome, whereas loss of 1p, 3p and 11q, unbalanced gain of 17q and MYCN amplification (MNA) are indicative of h...
journal_title:Carcinogenesis
pub_type: 杂志文章,多中心研究,评审
doi:10.1093/carcin/bgh173
更新日期:2004-09-01 00:00:00
abstract::Soy-based products consumed in Asian countries are minimally processed whereas in the USA many of the soy foods and soy ingredients are highly processed. Soy foods contain complex mixtures of bioactive compounds, which may interact with one another. The objective of this study was to evaluate the ability of various so...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh178
更新日期:2004-09-01 00:00:00
abstract::There is increasing concern that compounds formed during the chemical or biological transformation of pollutants in the environment may be more detrimental to human and environmental health than the original pollutant. In this study, two bacterial transformation products of polycyclic aromatic hydrocarbons (PAHs), pyr...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh174
更新日期:2004-09-01 00:00:00
abstract::To investigate the mechanistic basis for the biological properties of anthocyanins, two aglycone anthocyanins [delphinidin (DY) and cyanidin (CY)] were used to examine their effects on cell cycle progression and on induction of apoptosis in human cancer cells (uterine carcinoma and colon adenocarcinoma cells) and in n...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh138
更新日期:2004-08-01 00:00:00
abstract::Epidemiological investigations suggest that chronic lung inflammation increases lung cancer risk. Pharmacologic and genetic evidence in mouse models indicates that lipid mediators released during pulmonary inflammation enhance lung tumor formation. Cytosolic phospholipase A2 (cPLA2) catalyzes arachidonic acid (AA) rel...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh150
更新日期:2004-08-01 00:00:00
abstract::Supplementation by beta-carotene has unexpectedly appeared to increase lung cancer risk among smokers. In order to explain this it has been suggested that at high serum levels of beta-carotene, prooxidant characteristics of beta-carotene may become manifest, yielding reactive oxygen species (ROS) and inducing oxidativ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh125
更新日期:2004-07-01 00:00:00
abstract::The aims of this study were to examine the anti-proliferative effects of different concentrations of a commercial preparation of conjugated linoleic acids (CLA) mixture of isomers [cis-9, trans-11 CLA (c9,t11 CLA): trans-10, cis-12 CLA (50:50)] and their constituent isomers on PC-3, a human prostatic carcinoma cell li...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh116
更新日期:2004-07-01 00:00:00
abstract::The steroid hormone 1,25-dihydroxyvitamin D(3), [1,25(OH)(2)D(3), calcitriol], the active metabolite of vitamin D, exerts pleiotropic antitumor effects against several malignancies. However, the clinical use of this hormone is limited by hypercalcemia. 25-Hydroxyvitamin D(3), the prohormone of 1,25(OH)(2)D(3), is hydr...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh086
更新日期:2004-06-01 00:00:00
abstract::The association between prostate cancer risk and dietary fat consumption is well documented and explained partly by accelerated lipid peroxidation. We explored the possible effects of high dietary cholesterol on carcinogenesis and oxidative stress in the prostate of ACI/Seg rats. The rats develop prostate cancer spont...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh105
更新日期:2004-06-01 00:00:00
abstract::Tobacco smoking and occupational exposure are major risk factors of bladder cancer via exposure to polycyclic aromatic hydrocarbons (PAHs) and aromatic amines, which lead to oxidative stress and DNA damage. Several enzymes, which play key roles in oxidative stress are polymorphic in humans. Myeloperoxidase (MPO) produ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh080
更新日期:2004-06-01 00:00:00
abstract::A decreased incidence of squamous cell carcinoma of the head and neck (SCCHN) associated with fruit and vegetable intake may act through chemopreventive compounds, which may be more available to persons homozygous for the deletion genotypes of the glutathione S-transferase (GST). We evaluated interactions between frui...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh054
更新日期:2004-05-01 00:00:00
abstract::Prepubertal exposure to soy or its biologically active component genistein reduces later breast cancer risk in both animal models and human populations. We investigated whether that might be due to reported estrogenic properties of genistein. Our study indicated that daily prepubertal exposures between postnatal days ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh065
更新日期:2004-05-01 00:00:00
abstract::Estrogen production and metabolism play critical roles in the development and pathogenesis of endometrial carcinoma. Cytochrome P450 1B1 (CYP1B1) and catechol-O-methyltransferase (COMT) are two key enzymes in the estrogen metabolism pathway that result in the hydroxylation and conjugation of estradiol, respectively. W...
journal_title:Carcinogenesis
pub_type: 杂志文章,多中心研究
doi:10.1093/carcin/bgh039
更新日期:2004-04-01 00:00:00
abstract::In the previous 500 2-year chemical bioassays within the National Toxicology Program, large intestinal tumors (cecal carcinomas) related to chemical exposure have not been observed in B6C3F1 mice. The recently completed o-nitrotoluene study provided the first cecal tumor response and an opportunity to evaluate the mor...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh044
更新日期:2004-04-01 00:00:00
abstract::Not all carcinogens are mutagens, and many mutagens are not carcinogens. Among related chemicals, small changes of structure can markedly influence carcinogenic potency. Many tumours are genetically unstable, but some, especially 'benign' types, rarely exhibit 'progression' or show other evidence of genetic instabilit...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh013
更新日期:2004-03-01 00:00:00
abstract::The PEA3/E1AF/ETV4 gene encodes an Ets-related transcription factor that is expressed in the epithelial cells of the mammary gland. Previous reports have shown that PEA3 can up-regulate promoter activities of many genes associated with tumorigenesis. A significant fraction of those encode matrix metalloproteinases (MM...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh024
更新日期:2004-03-01 00:00:00
abstract::Transforming growth factor-beta 1 (TGF-beta1) plays a significant role in regulating the proliferation and apoptosis of prostate epithelial and stromal cells. We explored the association between the T (Leu) to C (Pro) polymorphism at codon10 of the TGF-beta1 gene (TGFB1) and the risk of prostate cancer (PCa) or benign...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgg197
更新日期:2004-02-01 00:00:00
abstract::The phosphoinositide 3-kinase (PI 3-kinase) signaling pathway has been shown to play a pivotal role in intracellular signal transduction pathways involved in cell growth, cellular transformation and tumorigenesis. Analysis of several colon adenocarcinoma cell lines indicates that the PI 3-kinase signaling pathway is u...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgg195
更新日期:2004-02-01 00:00:00
abstract::Diallyl disulfide (DADS), a sulfur compound from garlic has been shown to exert many biological effects: induction of carcinogen detoxication, inhibition of tumor cell proliferation, etc. These effects are consistent with its anticarcinogenic properties in animal models and could account for garlic protective effects ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgg182
更新日期:2004-01-01 00:00:00
abstract::Peroxisome proliferator activated receptor(alpha) (PPARalpha) mediates the liver's responses to peroxisome proliferator compounds. These responses include induction of specific hepatic enzymes, peroxisome proliferation and hepatocyte proliferation. PPARalpha null mice, which lack receptor in all cells of the body, do ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgg180
更新日期:2004-01-01 00:00:00
abstract::The aim of the present study was to investigate the impact of four different lactobacillus (LB) strains, namely Lactobacillus bulgaricus 291, Streptococcus thermophilus F4, S.thermophilus V3 and Bifidobacterium longum BB536, which are used for the production of yogurt, on the DNA-damaging effects of heterocyclic aroma...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgg167
更新日期:2003-12-01 00:00:00